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Solidagonic acid

CAT: 0804-HY-N11128Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N11128Size:1 Each
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Description
Solidagonic acid inhibits HSET motor activity by promoting the conversion from abnormal monopolar to bipolar spindles. Solidagonic acid suppresses fission yeast cell death and enables reversion of the mitotic spindles from a monopolar to bipolar morphology. Solidagonic acid showed the growth inhibitory activity on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam[1][2].
CAS Number
19941-91-4
UNSPSC
12352211
Target
Kinesin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/solidagonic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C(CC[C@@]1([C@H]([C@H](C[C@]2(C)C(C)=CCC[C@H]21)OC(C)=O)C)C)\C)O
Molecular Formula
C22H34O4
Molecular Weight
362.50
References & Citations
[1]Naoaki Kurisawa, et al. Kolavenic acid analog restores growth in HSET-overproducing fission yeast cells and multipolar mitosis in MDA-MB-231 human cells. Bioorg Med Chem. 2020 Jan 1;28 (1) :115154.|[2]Hisashi Kato-Noguchi, et al. Allelopathy and Allelochemicals of Solidago canadensis L. and S. altissima L. for Their Naturalization. Plants (Basel) . 2022 Nov 25;11 (23) :3235.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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