HAMA Blocking Reagent

• Description:

  HAMA Blocking Reagent_x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_

  Catalog #	A2010010NP
  Size	10 mg
  Other Names	Heterophilic Immunoglobulin Blocking Reagent
  Concentration	2 mg/mL
  Purity	Partially purified
  Storage	2-8°C (short term). -20°C (long term). Avoid repeated freeze-thaw.
  Supplied as	Liquid solution
  Buffer	PBS 1x + 40% Glycerol
  Keywords	HAMA

  _x000D_  _x000D_ _x000D_ About HAMA_x000D_ _x000D_ For decades, immunoassays have relied heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer dramatically when patient samples contains human anti-mouse antibodies. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. This so-called HAMA problem is especially noticeable in patients receiving mouse antibodies therapies. Assessing the tolerance of an immunoassay to HAMA is a corner stone in assay development._x000D_ _x000D_ References Related to HAMA Blocking Reagent_x000D_ _x000D_

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  • Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. Clin Biochem. 1996 Apr;29(2):145-8.
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  • Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. Best Pract Res Clin Endocrinol Metab. 2013 Oct;27(5):647-61.
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  • Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. Clin Chim Acta. 2013 Nov 15;426:79-84.
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  • Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Gene. 2017 May 30;614:49-55.
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  • Hull B. Aberrantly elevated TSH level due to human anti-mouse antibodies (HAMA) interference with thyrotropin assay. J S C Med Assoc. 2012 Feb;108(1):12-3.
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  • Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. J Immunol Methods. 2011 Sep 30;372(1-2):204-8.
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  All Interference Products Brochure_x000D_

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• Short Description:

  Catalog #: A2010010NP - 10 mg_x000D_ _x000D_ The presence in human serum of Human Anti-Mouse antibodies (HAMA) is a major concern in immunoassays. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. The provided HAMA Blocking Reagent specifically binds to HAMA, minimizing their interference and significantly reducing the number of false positives. Simply spike our HAMA Blocking Reagent into your immunoassay reagent(s) to 5-50 ug/mL (optimum concentration is assay dependent)._x000D_ _x000D_ Live Enquiry about this product via Text/SMS: 1-858-900-3210 (8 am €“ 8 pm PST)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5