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HAMA Interference Kit

CAT: 0952-K2010009Size: 1 EachDry Ice: NoHazardous: No
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HAMA Interference Kit_x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_ _x000D_
Lot number:Lot dependent
Expiration date:Lot dependent
Package Size:1 kit, 6 samples (NS and PS1-PS5)
Other names:Human Anti-mouse Antibodies Interference Kit
KeywordsHama interference Testing, Hama Interference Immunoassays, Hama antibody interference, Hama bridging inference
Concentration: -20°C. Avoid repeated freeze-thaw.
_x000D_  _x000D_ _x000D_ About HAMA_x000D_ _x000D_ Immunoassays rely heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer when samples contain human anti-mouse antibodies (HAMA). Indeed, HAMA are often associated with inaccurate results because they can bind to both capture and detection antibodies and can generate non-specific signals. This so-called HAMA effect is major interference issue. Assessing the tolerance of an immunoassay to HAMA and mitigating it is very important important during research and development._x000D_ _x000D_ References_x000D_
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  • Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. Clin Biochem. 1996 Apr;29(2):145-8.
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  • Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. Best Pract Res Clin Endocrinol Metab. 2013 Oct;27(5):647-61.
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  • Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. Clin Chim Acta. 2013 Nov 15;426:79-84.
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  • Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Gene. 2017 May 30;614:49-55.
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  • Hull B. Aberrantly elevated TSH level due to human anti-mouse antibodies (HAMA) interference with thyrotropin assay. J S C Med Assoc. 2012 Feb;108(1):12-3.
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  • Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. J Immunol Methods. 2011 Sep 30;372(1-2):204-8.
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_x000D_ Products Related to HAMA Interference Kit_x000D_ _x000D_ https://moleculardepot.com/product/high-hama-serum/_x000D_ _x000D_ https://moleculardepot.com/product/interference-test-kit-for-assay-validation/
Short Description
Catalog #: K2010009
Weight
0.15
Length
2
Width
0.5
Height
0.5

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