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FKGK18

CAT: 0804-HY-115403-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115403-01Size:1 mg
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Description
FKGK18 is a selective group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor. FKGK18 is a fluoroketone (FK) -based compound with IC50s of 50 nM and 3 μM for iPLA2β and iPLA2γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes[1][2][3].
CAS Number
1071001-09-6
UNSPSC
12352005
Target
Apoptosis; Phospholipase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fkgk18.html
Purity
99.90
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(CCCCC1=CC=C2C=CC=CC2=C1)C(F)(F)F
Molecular Formula
C16H15F3O
Molecular Weight
280.28
References & Citations
[1]Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53 (9) :3602-10.|[2]Ali T, et al. Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β) : candidate drug for preventing beta-cell apoptosis and diabetes. PLoS One. 2013 Aug 20;8 (8) :e71748.|[3]Bone RN, et al. Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes. 2015 Feb;64 (2) :541-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1,1,1-Trifluoro-6-(naphthalen-2-yl)hexan-2-one

inhibits Group VIA Ca(II)-independent phospholipase A2; structure in first source

CAS Number1071001-09-6
PubChem CID25060069
IUPAC Name1,1,1-trifluoro-6-naphthalen-2-ylhexan-2-one
Molecular FormulaC16H15F3O
Molecular Weight280.28
XLogP5.5
Topological Polar Surface Area17.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count20
Formal Charge0
Complexity324
SMILES
C1=CC=C2C=C(C=CC2=C1)CCCCC(=O)C(F)(F)F
InChI
InChI=1S/C16H15F3O/c17-16(18,19)15(20)8-4-1-5-12-9-10-13-6-2-3-7-14(13)11-12/h2-3,6-7,9-11H,1,4-5,8H2
InChIKey
VCWWTQMRNJSJGC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,1,1-Trifluoro-6-(naphthalen-2-yl)hexan-2-one
CAS: 1071001-09-6
CID: 25060069
Formula: C16H15F3O
MW: 280.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight280.28
XLogP35.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass280.10749958
Monoisotopic Mass280.10749958
Topological Polar Surface Area17.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity324
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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