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FKGK11

CAT: 0804-HY-116018Size: 1 mg (17.84 mM x 200 μL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-116018Size:1 mg (17.84 mM x 200 μL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2) . FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].
CAS Number
1071000-98-0
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fkgk11.html
Concentration
17.84 mM * 200 μL in Ethanol
Purity
99.00
Solubility
10 mM in DMSO
Smiles
O=C(C(F)(C(F)(F)F)F)CCCCC1=CC=CC=C1
Molecular Formula
C13H13F5O
Molecular Weight
280.23
References & Citations
[1]Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53 (9) :3602-10.|[2]Yan Xu, et al. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment. Cancer Res (2011) 71 (8_Supplement) : 3525.|[3]López-Vales R, et al. Intracellular phospholipase A (2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct;131 (Pt 10) :2620-31.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Phospholipase A

Chemical Information

1,1,1,2,2-Pentafluoro-7-phenylheptan-3-one

FKGK 11 is a member of benzenes.

CAS Number1071000-98-0
PubChem CID24995215
IUPAC Name1,1,1,2,2-pentafluoro-7-phenylheptan-3-one
Molecular FormulaC13H13F5O
Molecular Weight280.23
XLogP4.5
Topological Polar Surface Area17.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count19
Formal Charge0
Complexity292
SMILES
C1=CC=C(C=C1)CCCCC(=O)C(C(F)(F)F)(F)F
InChI
InChI=1S/C13H13F5O/c14-12(15,13(16,17)18)11(19)9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2
InChIKey
ROPVXAWEVYWEQY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,1,1,2,2-Pentafluoro-7-phenylheptan-3-one
CAS: 1071000-98-0
CID: 24995215
Formula: C13H13F5O
MW: 280.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight280.23
XLogP34.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass280.08865584
Monoisotopic Mass280.08865584
Topological Polar Surface Area17.1 Ų
Heavy Atom Count19
Formal Charge0
Complexity292
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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