HB-3-20

• UNSPSC Description:

  HB-3-20 leads to degradation of the cell surface integrin αVβ5. Transglutaminase 2 (TG2) has specificity for HB-3-20 (kcat/KM=0.16 μM-1min-1)[1].

• Target Antigen:

  Integrin

• Type:

  Peptides

• Related Pathways:

  Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hb-3-20.html

• Smiles:

  O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(NCC(NCC(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]4N(C(C)=O)CCC4

• Molecular Weight:

  1531.67

• References & Citations:

  [1]Elise Loppinet, et al. Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. J Am Chem Soc. 2023 Aug 30;145(34):18705-18710.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported