KB02-JQ1
CAT:
804-HY-129917-01
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KB02-JQ1
- CAS Number: 2384184-44-3
- UNSPSC Description: KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1[1].
- Target Antigen: Epigenetic Reader Domain; PROTACs
- Type: Reference compound
- Related Pathways: Epigenetics;PROTAC
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kb02-jq1.html
- Purity: 99.17
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(NCCOCCOCCNC(C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)=O)COC5=CC6=C(N(C(CCl)=O)CCC6)C=C5
- Molecular Weight: 796.76
- References & Citations: [1]Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported