DLK-IN-1

DLK-IN-1

• Product Name Alternative: TC-1734; ACD3480
• CAS Number: 1620574-24-4
• UNSPSC Description: DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.
• Target Antigen: MAP3K
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/DLK-IN-1.html
• Purity: 99.18
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C
• Molecular Weight: 423.43
• References & Citations: [1]Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported