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DLK-IN-1

CAT: 0804-HY-114331-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114331-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DLK-IN-1 (Compound 14) is an orally active, blood-brain barrier-penetrable and selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a Ki value of 3 nM. DLK-IN-1 inhibits Flt3, PAK4, STK33 and TrkA. DLK-IN-1 reduces p-c-Jun. DLK-IN-1 can be used in Alzheimer's disease research[1].
CAS Number
1620574-24-4
Product Name Alternative
TC-1734; ACD3480
UNSPSC
12352005
Target
FLT3; MAP3K; PAK; STK33; Trk Receptor
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DLK-IN-1.html
Concentration
10mM
Purity
99.18
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C
Molecular Formula
C20H24F3N5O2
Molecular Weight
423.43
References & Citations
[1]Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60 (19) :8083-8102.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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