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KAR425

CAT: 0804-HY-116552Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116552Size:1 Each
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Description
KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC50 values of 62 nM, 55 nM, and 60 nM, respectively[1].
CAS Number
1809050-49-4
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kar425.html
Smiles
CCC1=C(C)/C(N=C1C2=CC=CN2)=C\NC3CCCCCC3
Molecular Formula
C19H27N3
Molecular Weight
297.44
References & Citations
[1]Papireddy Kancharla, et al. Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials. J Med Chem. 2015 Sep 24;58 (18) :7286-309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-cycloheptyl-1-[4-ethyl-3-methyl-5-(1H-pyrrol-2-yl)-1H-pyrrol-2-yl]methanimine
CAS Number1809050-49-4
PubChem CID137053716
IUPAC NameN-cycloheptyl-1-[4-ethyl-3-methyl-5-(1H-pyrrol-2-yl)-1H-pyrrol-2-yl]methanimine
Molecular FormulaC19H27N3
Molecular Weight297.4
XLogP4.6
Topological Polar Surface Area43.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity360
SMILES
CCC1=C(NC(=C1C)C=NC2CCCCCC2)C3=CC=CN3
InChI
InChI=1S/C19H27N3/c1-3-16-14(2)18(22-19(16)17-11-8-12-20-17)13-21-15-9-6-4-5-7-10-15/h8,11-13,15,20,22H,3-7,9-10H2,1-2H3
InChIKey
OYOINSWGRZZRQK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-cycloheptyl-1-[4-ethyl-3-methyl-5-(1H-pyrrol-2-yl)-1H-pyrrol-2-yl]methanimine
CAS: 1809050-49-4
CID: 137053716
Formula: C19H27N3
MW: 297.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight297.4
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Exact Mass297.220497874
Monoisotopic Mass297.220497874
Topological Polar Surface Area43.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity360
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19197380-01KAR425

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