Klotho-derived peptide 1 (hydrochloride)
CAT:
804-HY-P10414A-02
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Klotho-derived peptide 1 (hydrochloride)
- UNSPSC Description: Klotho-derived peptide 1 (KP1 human) hydrochloride blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model[1].
- Target Antigen: p38 MAPK; TGF-beta/Smad
- Type: Peptides
- Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt;TGF-beta/Smad
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/klotho-derived-peptide-1-hydrochloride.html
- Purity: 97.28
- Solubility: 0.1 M Acetic acid : 50 mg/mL (adjust pH to 2 with CH3COOH)|H2O : 50 mg/mL (ultrasonic)
- Smiles: [Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly (HCl salt)]
- Molecular Weight: 3228.44 (free base)
- References & Citations: [1]Yuan Q, et al., A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 2022 Jan 21;13(1):438.
- Shipping Conditions: Blue Ice
- Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported