Klotho-derived peptide 1

Klotho-derived peptide 1

• UNSPSC Description: Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model[1].
• Target Antigen: p38 MAPK; TGF-beta/Smad
• Type: Peptides
• Related Pathways: MAPK/ERK Pathway;Stem Cell/Wnt;TGF-beta/Smad
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/klotho-derived-peptide-1.html
• Smiles: O=C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(NCC(NCC(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC9=CNC=N9)C(NCC(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%10=CC=CC=C%10)N
• Molecular Weight: 3228.44
• References & Citations: [1]Yuan Q, et al., A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 2022 Jan 21;13(1):438.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported