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Mitraphylline

CAT: 0804-HY-N6946-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6946-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo[1][2][3].
CAS Number
509-80-8
UNSPSC
12352005
Hazard Statement
H300
Target
Interleukin Related; NF-κB
Type
Natural Products
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mitraphylline.html
Purity
99.30
Solubility
DMSO : 6.76 mg/mL (ultrasonic)
Smiles
O=C1NC2=C([C@@]13CCN4C[C@@]5([C@@H](OC=C([C@]5(C[C@]43[H])[H])C(OC)=O)C)[H])C=CC=C2
Molecular Formula
C21H24N2O4
Molecular Weight
368.43
Precautions
H300
References & Citations
[1]Montserrat-de la Paz S, et al. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine. 2016 Feb 15;23 (2) :141-8.|[2]Rojas-Duran, R., et al., (2012) . Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of ethnopharmacology, 143 (3), 801–804.|[3]García Prado, E., et al., (2007) . Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine : international journal of phytotherapy and phytopharmacology, 14 (4), 280–284.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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