QDPR-IN-1

• UNSPSC Description:

  QDPR-IN-1 (Compound 9b) is a potent QDPR inhibitor with an IC50 of 0.72 μM[1].

• Target Antigen:

  Dihydrofolate reductase (DHFR)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/qdpr-in-1.html

• Purity:

  99.28

• Solubility:

  DMSO : 3.12 mg/mL (ultrasonic;adjust pH to 4 with 1 M HCL)

• Smiles:

  O=C1NNC(C2=CC(N(CC)CC)=CC=C12)=O

• Molecular Weight:

  233.27

• References & Citations:

  [1]Hara S, et al. Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate. Biochem Biophys Res Commun. 2024 Jul 12;717:150059.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  29415-71-2