Anti-MRSA agent 18

• UNSPSC Description:

  Anti-MRSA agent 18 (E17) is an inhibitor of MRSA with MIC values of 2 μg/mL for S. aureus and 4 μg/mL for MRSA, respectively. Anti-MRSA agent 18 interacts with bacterial cell membrane phosphatidylglycerol and cardiolipin, causing changes in cell membrane permeability and polarization, increased intracellular ROS, and DNA and protein leakage, thereby accelerating bacterial death[1].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/anti-mrsa-agent-18.html

• Smiles:

  C=CCC1=C(C=CC(C2=C3OC(C4=C(C=CC=C4Cl)Cl)=NC3=CC(CC=C)=C2)=C1)OCCC[N+](C)(CC(NCCCC)=O)C.[Br-]

• Molecular Weight:

  715.55

• References & Citations:

  [1]Yang R, et al. Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus. J Med Chem. 2024 Sep 26;67(18):16858-16872.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4