ATC-324

• UNSPSC Description:

  ATC-324 is an bivalent AR (Androgen Receptor) degrader based on the protein degradation technology platform AUTOphagy-TArgeting Chimera (AUTOTAC). ATC-324 induces the formation of AR/p62 complex, leading to autophagy-lysosomal degradation of AR. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa[1]. ATC-324 is composed of target-binding ligand (TBL) Enzalutamide (HY-70002) and p62/SQSTM1 autophagy-targeting ligand (ATL) YT 6-2 analog-1 (HY-169386), connected by Boc-NH-PEG4-CH2CH2NH2 (HY-W008352). Among them, the active control of the target protein ligand is Enzalutamide carboxylic acid (HY-70002B), and the conjugate composed of the autophagy-targeting ligand and the linker is YT 6-2-PEG3-C2-NH2 (HY-169387).

• Target Antigen:

  Androgen Receptor; AUTOTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/atc-324.html

• Smiles:

  O=C(NCCOCCOCCOCCOCCNC[C@@H](O)COC1=CC=C(OCC2=CC=C(F)C=C2)C(OCC3=CC=C(F)C=C3)=C1)C4=CC=C(N(C(N5C6=CC=C(C#N)C(C(F)(F)F)=C6)=S)C(C)(C)C5=O)C=C4F

• Molecular Weight:

  1068.09

• References & Citations:

  [1]Bae TH, et al. An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer. Cancer Res. 2024 Nov 12.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported