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PNSC928

CAT: 0804-HY-159131Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-159131Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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UNSPSC Description
PNSC928 is an inhibitor for the CtBP2-p300 interaction with an IC50 of 23.60 µM, and reverses the Lipopolysaccharides (HY-D1056)-induced expressions of proinflammatory cytokines in RAW264.7. PNSC928 ameliorates the acute respiratory distress syndrome (ARDS)in mice[1].
Target Antigen
Epigenetic Reader Domain; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pnsc928.html
Smiles
O=C(C1)OC[C@]1([H])[C@@]2([H])CC=C(CC/C=C(C)/CCC3=C(C)CCCC3(C)C)[C@@](O)([H])O2
Molecular Weight
402.57
References & Citations
[1]Li F, et al., PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome. Biol Direct. 2024 Jun 21;19(1):48.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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CatalogName
T210257-01PNSC928

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