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Glychionide A

CAT: 0804-HY-N8034Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8034Size:5 mg
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Description
Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].
CAS Number
119152-50-0
UNSPSC
12352005
Target
Apoptosis; Autophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/glychionide-a.html
Purity
97.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C(OC(C2=CC=CC=C2)=C1)=C3O)=C(C=C3O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)C(O)=O)O
Molecular Formula
C21H18O11
Molecular Weight
446.36
References & Citations
[1]Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7 (4) :677-80.|[2]Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb 3;25:962-969.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Glychionide A

glychionide a has been reported in Glycyrrhiza glabra with data available.

CAS Number119152-50-0
PubChem CID11597485
IUPAC Name(2S,3S,4S,5R,6S)-6-(5,8-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Molecular FormulaC21H18O11
Molecular Weight446.4
XLogP1.1
Topological Polar Surface Area183
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Heavy Atom Count32
Formal Charge0
Complexity748
SMILES
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)O)O)O)O)O
InChI
InChI=1S/C21H18O11/c22-9-6-11(8-4-2-1-3-5-8)30-18-13(9)10(23)7-12(14(18)24)31-21-17(27)15(25)16(26)19(32-21)20(28)29/h1-7,15-17,19,21,23-27H,(H,28,29)/t15-,16-,17+,19-,21+/m0/s1
InChIKey
MOFOLNOWFPVLGZ-BHWDSYMASA-N
Chemical Structure
2D Structure
2D structure of Glychionide A
CAS: 119152-50-0
CID: 11597485
Formula: C21H18O11
MW: 446.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight446.4
XLogP31.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass446.08491139
Monoisotopic Mass446.08491139
Topological Polar Surface Area183 Ų
Heavy Atom Count32
Formal Charge0
Complexity748
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
UEA15250-01Glychionide A

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