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IP3 receptor/ITPR1 Rabbit Polyclonal Antibody

CAT: 0013-GTR17691399Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR17691399Size:100 µg
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Description
IP3 receptor/ITPR1 Rabbit Polyclonal Antibody
Product Name Alternative
Inositol 1, 4, 5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1, 4, 5-trisphosphate receptor; Type 1 InsP3 receptor; ITPR1; INSP3R1
UniProt
Q14643
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human IP3 receptor recombinant protein (Position: A2411-A2758) . Human IP3 receptor shares 98% and 97% amino acid (aa) sequences identity with mouse and rat IP3 receptor, respectively.
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cancer Biology, Cell Biology, Metabolism Research, Signal Transduction
Purification
Immunogen affinity purified.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Dilution
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2μg/ml, Human Flow Cytometry (Fixed), 1-3μg/1x10^6 cells, Human
Form
Lyophilized
Molecular Weight
290 kDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
FC, ICC, IF, IHC, WB
Host or Source
Rabbit
Preservative
Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg NaN3. *This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.
Isotype
Rabbit IgG

UniProtKB · Q14643

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

ITPR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14643
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITPR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
E7EPX7, E9PDE9, Q14660, Q99897
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCalcium transportIon transportTransport

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingZinc

Molecular function

Calcium channelIon channelLigand-gated ion channelReceptor

Cellular component

CytoplasmCytoplasmic vesicleEndoplasmic reticulumMembrane

Disease

Disease variantIntellectual disabilityNeurodegenerationSpinocerebellar ataxia

PTM

Disulfide bondGlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix

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