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Flurofamide

CAT: 0804-HY-100956-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100956-04Size:10 mg
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Description
Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones[1][2][3][4].
CAS Number
70788-28-2
UNSPSC
12352005
Target
Bacterial; Urease
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/flurofamide.html
Purity
92.6
Solubility
DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NP(N)(N)=O)C1=CC=C(F)C=C1
Molecular Formula
C7H9FN3O2P
Molecular Weight
217.14
References & Citations
[1]Millner OE Jr, et al. Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones. J Urol. 1982 Feb;127 (2) :346-50.|[2]Fleming D, et al. Flurofamide Prevention and Treatment of Ureaplasma-Induced Hyperammonemia. Microbiol Spectr. 2022 Oct 26;10 (5) :e0192722.|[3]Nakamura H, et al. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment. Infect Immun. 1998 Oct;66 (10) :4832-7. |[4]Kenny GE. Inhibition of the growth of Ureaplasma urealyticum by a new urease inhibitor, flurofamide. Yale J Biol Med. 1983 Sep-Dec;56 (5-6) :717-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(Diaminophosphinyl)-4-fluorobenzamide

N-diaminophosphoryl-4-fluorobenzamide is an organohalogen compound and a carbonyl compound.

CAS Number70788-28-2
PubChem CID51173
IUPAC NameN-diaminophosphoryl-4-fluorobenzamide
Molecular FormulaC7H9FN3O2P
Molecular Weight217.14
XLogP-0.6
Topological Polar Surface Area98.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count14
Formal Charge0
Complexity260
SMILES
C1=CC(=CC=C1C(=O)NP(=O)(N)N)F
InChI
InChI=1S/C7H9FN3O2P/c8-6-3-1-5(2-4-6)7(12)11-14(9,10)13/h1-4H,(H5,9,10,11,12,13)
InChIKey
QWZFVMCWPLMLTL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(Diaminophosphinyl)-4-fluorobenzamide
CAS: 70788-28-2
CID: 51173
Formula: C7H9FN3O2P
MW: 217.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight217.14
XLogP3-0.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass217.04164170
Monoisotopic Mass217.04164170
Topological Polar Surface Area98.2 Ų
Heavy Atom Count14
Formal Charge0
Complexity260
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3614862-01Flurofamide
TRC-F596687-5MGFlurofamide-d4

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