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Flurofamide

CAT: 0804-HY-100956-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100956-01Size:1 mg
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Description
Flurofamide is an effective bacterial urease inhibitor and antibacterial agent. Flurofamide inhibits urease and partially inhibits the chemotactic activity of Helicobacter pylori strain CPY3401. Flurofamide inhibits the growth of Ureaplasma urealyticum. Flurofamide reduces blood ammonia. Flurofamide can be used in the research of infectious urinary stones[1][2][3][4].
CAS Number
70788-28-2
UNSPSC
12352005
Target
Bacterial; Urease
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/flurofamide.html
Purity
92.6
Solubility
DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NP(N)(N)=O)C1=CC=C(F)C=C1
Molecular Formula
C7H9FN3O2P
Molecular Weight
217.14
References & Citations
[1]Millner OE Jr, et al. Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones. J Urol. 1982 Feb;127 (2) :346-50.|[2]Fleming D, et al. Flurofamide Prevention and Treatment of Ureaplasma-Induced Hyperammonemia. Microbiol Spectr. 2022 Oct 26;10 (5) :e0192722.|[3]Nakamura H, et al. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment. Infect Immun. 1998 Oct;66 (10) :4832-7. |[4]Kenny GE. Inhibition of the growth of Ureaplasma urealyticum by a new urease inhibitor, flurofamide. Yale J Biol Med. 1983 Sep-Dec;56 (5-6) :717-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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