17(R)-Resolvin D1

17(R)-Resolvin D1

• Product Name Alternative: 17(R)-RvD1; AT-RvD1
• CAS Number: 528583-91-7
• UNSPSC Description: 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy[2].
• Target Antigen: TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/17-r-resolvin-d1.html
• Purity: 99.1
• Solubility: 10 mM in DMSO
• Smiles: CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
• Molecular Weight: 376.49
• References & Citations: [1]Sun YP, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282(13):9323-9334.|[2]Bang S, et al., 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C, protect from light
• Clinical Information: No Development Reported