DD-03-156

DD-03-156

• CAS Number: 2769753-69-5
• UNSPSC Description: DD-03-156 is a potent and selective degrader of CDK17 and LIMK2. The selectivity and potency of DD-03-156 is exquisite and makes an advanced starting point for the development of a chemical probe for the degradation of CDK17 (Blue: VHL ligand (HY-112078), Black: linker HY-124380 (HY-124380)；Pink: BRAF inhibitor (HY-14660))[1].
• Target Antigen: CDK; LIM Kinase (LIMK); PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dd-03-156.html
• Smiles: CC(C)(C)C(S1)=NC(C2=CC=CC(NS(C3=C(F)C=CC=C3F)(=O)=O)=C2F)=C1C4=NC(NCCOCCOCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=NC=C4
• Molecular Weight: 1106.31
• References & Citations: [1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10.
• Shipping Conditions: Blue Ice