Fasedienol

CAT: 0804-HY-145567-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-145567-01Size:5 mg

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Description

Fasedienol (PH94B) is a neurochemical stimulator of the vomeronasal organ (VON) . Fasedienol significantly increases Ca++. Fasedienol modulates the olfactory amygdala circuitry of fear and anxiety to alleviate symptoms of PMS and anxiety[1][2][3].

CAS Number

23062-06-8

Product Name Alternative

PH94B

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fasedienol.html

Concentration

10mM

Purity

99.68

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](CCC1=C[C@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C=CC4)C

Molecular Formula

C19H28O

Molecular Weight

272.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Clive L. Jennings-White, et al. Steroids as neurochemical stimulators of the vno to alleviate symptoms of anxiety. Patent WO1998014194A1.|[2]Monti L, et al. Effect of fasedienol (PH94B) pherine nasal spray and steroidal hormones on electrogram responses and autonomic nervous system activity in healthy adult volunteers[J]. Human Psychopharmacology: Clinical and Experimental, 2024, 39 (2) : e2892.|[3]Monti L, et al. Neural circuits of anxiolytic and antidepressant pherine molecules. CNS Spectr. 2022 Feb;27 (1) :66-72.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Chemical Information

Ph94b

PH94B is being developed by Pherin Pharmaceuticals, Inc. for the treatment of social phobias (generalized anxiety disorder). It is a member of a new family of pharmaceutical compounds called vomeropherins.

CAS Number	23062-06-8
PubChem CID	9925482
IUPAC Name	(3S,8S,9S,10R,13R,14S)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
Molecular Formula	C19H28O
Molecular Weight	272.4
XLogP	4.6
Topological Polar Surface Area	20.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Heavy Atom Count	20
Formal Charge	0
Complexity	476

SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CC=C2)CCC4=C[C@H](CC[C@]34C)O

InChI

InChI=1S/C19H28O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h3,9,12,14-17,20H,4-8,10-11H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChIKey

NYVFCEPOUVGTNP-DYKIIFRCSA-N

Chemical Structure

2D Structure

CAS: 23062-06-8

CID: 9925482

Formula: C19H28O

MW: 272.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	272.4
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	272.214015512
Monoisotopic Mass	272.214015512
Topological Polar Surface Area	20.2 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	476
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
YAA06206-01	Fasedienol

Fasedienol

Chemical Information

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