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ZL0454

CAT: 0804-HY-112150-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112150-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.
CAS Number
2229042-77-5
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ZL0454.html
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C)C=C(/N=N/C2=CC=C(S(NC3CCCC3)(=O)=O)C=C2)C(N)=C1
Molecular Formula
C18H22N4O3S
Molecular Weight
374.46
References & Citations
[1]Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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