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Lobeline

CAT: 0804-HY-B1423Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1423Size:1 Each
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Description
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation[1][2].
CAS Number
90-69-7
Product Name Alternative
α-Lobeline; L-Lobeline
UNSPSC
12352005
Hazard Statement
H301+H311+H331
Target
Dopamine Transporter; nAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lobeline.html
Solubility
10 mM in DMSO
Smiles
CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3
Molecular Formula
C22H27NO2
Molecular Weight
337.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
References & Citations
[1]Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280 (3) :1432-44. |[2]Monzurul Amin Roni, et al. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017 Jun:61:63-70.|[3]Harrod SB, et al. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul;298 (1) :172-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Phase 2

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