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Saikogenin D

CAT: 0804-HY-N4237-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4237-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].
CAS Number
5573-16-0
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Potassium Channel; Prostaglandin Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/saikogenin-d.html
Purity
99.99
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@]12[C@]3(C(C=C[C@]1([H])[C@@]4([C@@]([C@@](C)([C@@H](O)CC4)CO)([H])CC2)C)=C5[C@](CO)(CCC(C)(C)C5)[C@H](O)C3)C
Molecular Formula
C30H48O4
Molecular Weight
472.70
Precautions
H315, H319
References & Citations
[1]Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E (2) synthesis.J Pharm Pharmacol. 2006 Jun;58 (6) :859-66.|[2]Kodama Y, et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Med. 2003 Aug;69 (8) :765-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
EP

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