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Fmoc- (D-Phe) -OSu

CAT: 0804-HY-W097109ASize: 1 EachDry Ice: NoHazardous: No
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Description
Fmoc- (D-Phe) -Osu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
CAS Number
182410-73-7
UNSPSC
12352005
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-d-phe-osu.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=O)N1OC([C@@H](CC2=CC=CC=C2)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O
Molecular Formula
C28H24N2O6
Molecular Weight
484.50
References & Citations
[1]Geoffrey C. Winters, et al. Sulfonamide-containing linkage systems for drug conjugates. WO2015095953A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cleavable Linker

Chemical Information

Fmoc-(D-Phe)-OSu
CAS Number182410-73-7
PubChem CID16658519
IUPAC Name(2,5-dioxopyrrolidin-1-yl) (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoate
Molecular FormulaC28H24N2O6
Molecular Weight484.5
XLogP4.1
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count36
Formal Charge0
Complexity802
SMILES
C1CC(=O)N(C1=O)OC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
InChI
InChI=1S/C28H24N2O6/c31-25-14-15-26(32)30(25)36-27(33)24(16-18-8-2-1-3-9-18)29-28(34)35-17-23-21-12-6-4-10-19(21)20-11-5-7-13-22(20)23/h1-13,23-24H,14-17H2,(H,29,34)/t24-/m1/s1
InChIKey
VLXHZQQUTCVLGU-XMMPIXPASA-N
Chemical Structure
2D Structure
2D structure of Fmoc-(D-Phe)-OSu
CAS: 182410-73-7
CID: 16658519
Formula: C28H24N2O6
MW: 484.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight484.5
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass484.16343649
Monoisotopic Mass484.16343649
Topological Polar Surface Area102 Ų
Heavy Atom Count36
Formal Charge0
Complexity802
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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