Thalidomide-5-O-C3-NH2 (hydrochloride)

CAT:

804-HY-149560-01

Size:

10 mg

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CAS Number: 2694727-94-9
UNSPSC Description: Thalidomide-5-O-C3-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type: Reference compound
Related Pathways: Apoptosis;Autophagy;PROTAC
Applications: Cancer-programmed cell death
Field of Research: cancer
Assay Protocol: https://www.medchemexpress.com/thalidomide-5-o-c3-nh2-hydrochloride.html
Solubility: 10 mM in DMSO
Smiles: O=C1C(C=CC(OCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl
Molecular Weight: 367.78
References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
Shipping Conditions: Blue Ice
Clinical Information: No Development Reported

Cat	Name
HY-149560-02	Thalidomide-5-O-C3-NH2 (hydrochloride)
HY-149560-01	Thalidomide-5-O-C3-NH2 (hydrochloride)
HY-138847A	Thalidomide-4-O-C3-NH2 (hydrochloride)
HY-138847	Thalidomide-O-C3-NH2
HY-139545	Thalidomide-4-C3-NH2 (hydrochloride)
HY-115560	Thalidomide-O-amido-C3-NH2
HY-149571-02	Thalidomide-5-O-C14-NH2 (hydrochloride)
HY-149570-01	Thalidomide-5-O-C13-NH2 (hydrochloride)
HY-149569-03	Thalidomide-5-O-C12-NH2 (hydrochloride)
HY-149569-02	Thalidomide-5-O-C12-NH2 (hydrochloride)

Cat	Name
T39894-1mg	Thalidomide-4-C3-NH2 hydrochloride
T39894-5mg	Thalidomide-4-C3-NH2 hydrochloride
T39894-1g	Thalidomide-4-C3-NH2 hydrochloride
MBS5800274	Thalidomide-4-C3-NH2 hydrochloride
T39894-10mg	Thalidomide-4-C3-NH2 hydrochloride
T39894-50mg	Thalidomide-4-C3-NH2 hydrochloride
T39426-1mg	Thalidomide-O-amido-C3-NH2
T39426-10mg	Thalidomide-O-amido-C3-NH2
T39426-50mg	Thalidomide-O-amido-C3-NH2
T39426-1g	Thalidomide-O-amido-C3-NH2