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Lonaprisan

CAT: 0804-HY-16290Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16290Size:1 Each
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Description
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA -induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect[1].
CAS Number
211254-73-8
Product Name Alternative
ZK 230211; BAY86 5044
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Progesterone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/lonaprisan.html
Smiles
O=C1CCC2=C3[C@@H](C4=CC=C(C(C)=O)C=C4)C[C@@]5(C)[C@](CC[C@@]5(O)C(F)(C(F)(F)F)F)([H])[C@]3([H])CCC2=C1
Molecular Formula
C28H29F5O3
Molecular Weight
508.52
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Fuhrmann U, et al., Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem. 2000 Dec 28;43 (26) :5010-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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MBS5812439Lonaprisan
A14130-100Lonaprisan 100mg
A14130-10Lonaprisan 10mg
A14130-50Lonaprisan 50mg
A14130-25Lonaprisan 25mg
A14130-5Lonaprisan 5mg

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