Falcarindiol

• Description :

  Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2]. Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352211

• Target :

  Apoptosis; Autophagy; PPAR

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/falcarindiol.html

• Purity :

  99.48

• Solubility :

  DMSO : ≥ 33.33 mg/mL

• Smiles :

  C=C[C@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC

• Molecular Formula :

  C17H24O2

• Molecular Weight :

  260.37

• References & Citations :

  [1]Tingting Lu, et al. Autophagy contributes to falcarindiol-induced cell death in breast cancer cells with enhanced endoplasmic reticulum stress. PLoS One. 2017 Apr 25;12 (4) :e0176348.|[2]Camilla Bertel Andersen, et al. Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models. Front Pharmacol. 2020 Aug 28;11:565524.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ

• CAS Number :

  [55297-87-5]