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BAI1 rabbit pAb

CAT: 0855-ES20822-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20822-01Size:50 µL
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Background
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family
Description
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family,
UniProt
O14514
Swiss Prot
O14514
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic Peptide of BAI1 AA range: 101-151
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
130-170kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130-170kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Cell projection, phagocytic cup . Cell junction, focal adhesion . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density .; [Vasculostatin-120]: Secreted .; [Vasculostatin-40]: Secreted .
Other Product Names
Brain-specific angiogenesis inhibitor 1
Gene ID (Human)
575

UniProtKB · O14514

Adhesion G protein-coupled receptor B1

AGRB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14514
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ADGRB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Cellular component

Cell junctionCell membraneCell projectionMembraneSecretedSynapse

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Molecular function

G protein-coupled receptorReceptorTransducer

Biological process

ImmunityInnate immunityMyogenesisNeurogenesisPhagocytosis

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

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