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PBOX-15

CAT: 0804-HY-124624Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124624Size:1 Each
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Description
PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells[1][2].
CAS Number
354759-10-7
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbox-15.html
Smiles
O=C(C)OC1=C(C2=C3C=CC=CC3=CC=C2)OC4=CC5=C(C=C4N6C=CC=C16)C=CC=C5
Molecular Formula
C28H19NO3
Molecular Weight
417.46
References & Citations
[1]Maginn EN, et al. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Br J Cancer. 2011 Jan 18;104 (2) :281-9.|[2]Mulligan JM, et al. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Mol Pharmacol. 2006 Jul;70 (1) :60-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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