PBOX-15

• Description :

  PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pbox-15.html

• Smiles :

  O=C(C)OC1=C(C2=C3C=CC=CC3=CC=C2)OC4=CC5=C(C=C4N6C=CC=C16)C=CC=C5

• Molecular Formula :

  C28H19NO3

• Molecular Weight :

  417.46

• References & Citations :

  [1]Maginn EN, et al. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Br J Cancer. 2011 Jan 18;104 (2) :281-9.|[2]Mulligan JM, et al. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Mol Pharmacol. 2006 Jul;70 (1) :60-70.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [354759-10-7]