DPPC-13C2

• UNSPSC Description:

  DPPC-13C2 is a deuterated labeled DPPC[1]. DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice[2][3][4][5][6].

• Target Antigen:

  Endogenous Metabolite; Isotope-Labeled Compounds; Liposome

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease;Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/dppc-13c2.html

• Purity:

  95.0

• Smiles:

  CCCCCCCCCCCCCCC[13C](O[C@H](CO[13C](CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O

• Molecular Weight:

  736.02

• References & Citations:

  [1]Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.|[2]Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201.|[3]Ege C, et al. Insertion of Alzheimer's A beta 40 peptide into lipid monolayers. Biophys J. 2004 Sep;87(3):1732-40.|[4]Kalra VK, et al. Transport of amino acids in gamma-glutamyl transpeptidase-implanted human erythrocytes. J Biol Chem. 1981 Jun 10;256(11):5567-71.|[5]Leekumjorn S, et al. Molecular simulation study of structural and dynamic properties of mixed DPPC/DPPE bilayers. Biophys J. 2006 Jun 1;90(11):3951-65.|[6]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  65277-91-0