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ABCE1 antibody

CAT: 0710-FNab10351Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10351Size:100 µg
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Background
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Synonyms
ATP-binding cassette sub-family E member 1|2'-5'-oligoadenylate-binding protein|HuHP68|RNase L inhibitor|Ribonuclease 4 inhibitor (RNS4I) |ABCE1|RLI|RNASEL1|RNASELI|RNS4I
Gene ID
6059
UniProt
P61221
Host
Rabbit
Reactivity
Human
Immunogen
ATP-binding cassette, sub-family E (OABP), member 1
Target
ABCE1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-70 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
419-599

UniProtKB · P61221

ATP-binding cassette sub-family E member 1

ABCE1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61221
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ABCE1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.5.-
Processing
—
Secondary accessions
O88793, Q13181, Q13864, Q6NR76, Q96AL0, Q96B10, Q99K66
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

4Fe-4SATP-bindingIronIron-sulfurMetal-bindingNucleotide-binding

Molecular function

ChaperoneHydrolase

Cellular component

CytoplasmMitochondrion

Biological process

Host-virus interaction

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Domain

Repeat

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