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Cardionogen 1

CAT: 0804-HY-W011616Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W011616Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cardionogen 1 (CDNG1/vuc230) is a Wnt signaling pathway inhibitor that slows down Myc-induced liver tumorigenesis. Cardionogen 1 treatment of zebrafish embryos before gastrulation inhibits cardiomyocyte formation, whereas treatment during or after gastrulation induces cardiomyocyte formation. Cardionogen 1 has potential in research into cancer and cardiovascular disease[1][2].
CAS Number
577696-37-8
Product Name Alternative
CDNG1/vuc230
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cardionogen-1.html
Purity
99.21
Solubility
10 mM in DMSO
Smiles
C12=NN=C(C3=CC=CO3)N1N=C(C4CCCCC4)S2
Molecular Formula
C13H14N4OS
Molecular Weight
274.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Yan C, et al. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 2017 Apr 5;7:45796.|[2]Plowright AT, et al. Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents. Angew Chem Int Ed Engl. 2014 Apr 14;53 (16) :4056-75.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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