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Sudan IV-d6

CAT: 0804-HY-D0932SSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0932SSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sudan IV-d6 (Solvent Red 24-d6) is the deuterium labeled Sudan IV. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA) ) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections[1][2][3][4].
CAS Number
1014689-18-9
Product Name Alternative
Solvent Red 24-d6; C.I. 26105-d6
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; Biochemical Assay Reagents; Cytochrome P450; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease
Smiles
OC1=C([2H])C([2H])=C2C([2H])=C([2H])C([2H])=C([2H])C2=C1/N=N/C3=CC=C(C=C3C)/N=N/C4=CC=CC=C4C
Molecular Formula
C24H14D6N4O
Molecular Weight
386.48
References & Citations
[1]Refat NA, et al. The induction of cytochrome P450 1A1 by sudan dyes. J Biochem Mol Toxicol. 2008 Mar-Apr;22 (2) :77-84.|[2]Lu D, et al. Binding of Sudan II and Sudan IV to bovine serum albumin: comparison studies. Food Chem Toxicol. 2011 Dec;49 (12) :3158-64.|[3]Huang ST, et al. An ultrasensitive and selective fluorescence assay for Sudan I and III against the influence of Sudan II and IV. Biosens Bioelectron. 2013 Apr 15;42:136-40.|[4]Pérez-Sanz F, Riquelme-Pérez M, Martínez-Barba E, de la Peña-Moral J, Salazar Nicolás A, Carpes-Ruiz M, Esteban-Gil A, Legaz-García MDC, Parreño-González MA, Ramírez P, Martínez CM. Efficiency of Machine Learning Algorithms for the Determination of Macrovesicular Steatosis in Frozen Sections Stained with Sudan to Evaluate the Quality of the Graft in Liver Transplantation. Sensors (Basel) . 2021 Mar 12;21 (6) :1993.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CYP1