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R 1487

CAT: 0804-HY-14974-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14974-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R 1487 is an orally active and highly selective p38α mitogen-activated protein kinase inhibitor. R 1487 can be used in the study of rheumatoid arthritis[1].
CAS Number
449811-92-1
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-1487.html
Smiles
O=C1C(OC2=CC=C(F)C=C2F)=CC3=CN=C(NC4CCOCC4)N=C3N1C
Molecular Formula
C19H18F2N4O3
Molecular Weight
388.37
References & Citations
[1]Goldstein DM, et al. Discovery of 6- (2,4-difluorophenoxy) -2-[3-hydroxy-1- (2-hydroxyethyl) propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6- (2,4-difluorophenoxy) -8-methyl-2- (tetrahydro-2H-pyran-4-ylamino) pyrido[2,3-d]pyrimidin-7 (8H) -one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54 (7) :2255-65.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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