5 Lipoxygenase Rabbit Polyclonal Antibody

5 Lipoxygenase Rabbit Polyclonal Antibody

• Description: 5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes, lipid metabolites that induce contractions of airway smooth muscle and increase vascular permeability during anaphylaxis. The cellular localization of 5-LO varies between cell types. In activated blood polymorphonuclear leukocytes 5-LO undergoes calcium dependent translocation from the cytosol to the nuclear envelope. In alveolar macrophages, the majority of 5-LO is localized in the nucleus and, upon activation of these cells, intranuclear 5-LO binds to the nuclear membrane. This intracellular shuttling of 5-LO is dependent on the association with various signaling molecules, phosphorylation and the presence of a distinct
• Product Name Alternative: 5 LO antibody 5 LOX antibody 5-lipoxygenase antibody 5-LO antibody 5-LOX antibody 5LOX antibody 5LPG antibody ALOX 5 antibody Alox5 antibody Arachidonate 5 lipoxygenase antibody Arachidonate 5-lipoxygenase antibody arachidonic 5-lipoxygenase alpha-10 isoform antibody arachidonic 5-lipoxygenase delta-10-13 isoform antibody arachidonic 5-lipoxygenase delta-13 isoform antibody arachidonic 5-lipoxygenase delta-p10 isoform antibody Arachidonic acid 5 lipoxygenase antibody Leukotriene A4 synthase antibody LOG 5 antibody LOG5 antibody LOX5_HUMAN antibody MGC163204 antibody
• Abbreviation: 5-LO, 5-lipoxygenase, ALOX5, LOG5
• CAS Number: 9007-83-4
• Swiss Prot: P09917 Human, P48999 Mouse, P12527 Rat
• Cellular Locus: Cytoplasm, Membrane, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human 5 Lipoxygenase aa 121-165.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB
• Positive Control: Hela cell lysate, Jurkat cell lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 78 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No