MCL1 Rabbit Polyclonal Antibody

• Description:

  B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.

• Product Name Alternative:

  Bcl 2 related protein EAT/mcl1 antibody Bcl-2-like protein 3 antibody Bcl-2-related protein EAT/mcl1 antibody BCL2 related antibody Bcl2-L-3 antibody BCL2L3 antibody EAT antibody Induced myeloid leukemia cell differentiation protein Mcl 1 antibody Induced myeloid leukemia cell differentiation protein Mcl-1 antibody MCL 1 antibody MCL1 antibody MCL1-ES antibody mcl1/EAT antibody MCL1_HUMAN antibody MCL1L antibody MCL1S antibody MGC104264 antibody MGC1839 antibody Myeloid Cell Leukemia 1 antibody Myeloid cell leukemia ES antibody Myeloid cell leukemia sequence 1 antibody Myeloid cell leukemia sequence 1 BCL2 related antibody Myeloid cell leukemia sequence 1 isoform 1 antibody OTTHUMP00000032794 antibody OTTHUMP00000032795 antibody TM antibody

• Abbreviation:

  Bcl2-L-3

• Swiss Prot:

  Q07820 Human, P97287 Mouse

• Cellular Locus:

  Membrane. Cytoplasm. Mitochondrion.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide within human MCL1 aa 58-130.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  IF-Cell, IHC-P

• Positive Control:

  HepG2, SK-BR-3, SW480, human colon cancer tissue, human pancreas tissue, mouse prostate tissue.

• Concentration:

  1 mg/mL

• Dilution:

  IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  37 / 29 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4