TCF7L2/TCF4 Rabbit Polyclonal Antibody

TCF7L2/TCF4 Rabbit Polyclonal Antibody

• Description: TCF7L2 is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions within the cell. It is a member of the Wnt signaling pathway. Stimulation of the pathway leads to the association of β-catenin with BCL9, translocation to the nucleus, and association with TCF7L2, which in turn results in the activation of Wnt target genes, specifically repressing proglucagon synthesis in enteroendocrine cells. TCF7L2 is implicated in a large variety of diseases. Several single nucleotide polymorphisms are associated with type 2 diabetes. In European populations it was found to be a major determinant of type 2 risk. A frameshift mutation of TCF7L2 is implicated in colorectal cancer .Variants of the gene are most likely involved in many other cancer types
• Alternative Name: bHLHb19 antibody Class B basic helix-loop-helix protein 19 antibody E2 2 antibody FECD3 antibody Immunoglobulin transcription factor 2 antibody ITF 2 antibody ITF-2 antibody ITF2 antibody ITF2_HUMAN antibody MGC149723 antibody MGC149724 antibody PTHS antibody SEF 2 antibody SEF-2 antibody SEF2 1 antibody SEF2 1A antibody SEF2 1B antibody SEF2 1D antibody SEF2 antibody SL3 3 enhancer factor 2 antibody SL3-3 enhancer factor 2 antibody TCF 4 antibody TCF-4 antibody TCF4 antibody Transcription factor 4 antibody Transcription factor 4, isoform C antibody Transcription factor 4, isoform D antibody Transcription factor 4, isoform E antibody Transcription factor 4, isoform L antibody Transcription factor 4, isoform M antibody Transcription factor 4, isoform R antibody
• Abbreviation: T-cell factor 4,TCF-4,hTCF-4
• Swiss Prot: Q9NQB0 Human, Q924A0 Mouse, D3Z9D1 Rat
• Cellular Locus: Nucleus
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within N-terminalHuman TCF4 aa 1-50 / 619.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P, IF-Cell, FC
• Positive Control: Hela, HepG2, HCT116, SW480, rat kidney tissue, human tonsil tissue, human colon cancer tissue, human breast cancer tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000;IF-Cell: 1:500-1:2,000;IHC-P: 1:100-1:500;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 68 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No