Hsp90 alpha Mouse Monoclonal Antibody [A10-A5-D2]

Hsp90 alpha Mouse Monoclonal Antibody [A10-A5-D2]

• Description: The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.
• Product Name Alternative: EL52 antibody epididymis luminal secretory protein 52 antibody Heat shock 86 kDa antibody heat shock 90kD protein 1, alpha antibody Heat shock 90kD protein 1, alpha like 4 antibody heat shock 90kD protein, alpha-like 4 antibody Heat shock 90kDa protein 1 alpha antibody Heat shock protein 90kDa alpha (cytosolic) class A member 1 antibody Heat shock protein HSP 90-alpha antibody HS90A_HUMAN antibody HSP 86 antibody HSP86 antibody Hsp89 antibody HSP89A antibody Hsp90 antibody HSP90A antibody HSP90AA1 antibody HSP90ALPHA antibody HSP90N antibody HSPC1 antibody HSPCA antibody HSPCAL1 antibody HSPCAL4 antibody HSPN antibody LAP 2 antibody LAP2 antibody lipopolysaccharide-associated protein 2 antibody LPS-associated protein 2 antibody Renal carcinoma antigen NY-REN-38 antibody
• Abbreviation: HSP 86, HSP86, LAP-2, LPS-associated protein 2, HSP90AA1
• CAS Number: 9007-83-4
• Swiss Prot: P07900 Human
• Cellular Locus: Nucleus, Cytoplasm, Melanosome, Cell membrane, Mitochondrion.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Hsp90 alpha aa 1-50 / 732.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: Hela, PC12, NIH/3T3, SW480, Ags, human kidney tissue, human gastric carcinoma tissue, mouse testis tissue.
• Concentration: 2 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:200
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 90kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No