CSF-1-R Recombinant Rabbit Monoclonal Antibody [PD00-45]

CSF-1-R Recombinant Rabbit Monoclonal Antibody [PD00-45]

• Description: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway. The encoded protein is a single pass type I membrane protein and acts as the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSF1R through a process of oligomerization and trans-phosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases.
• Product Name Alternative: C FMS antibody CD 115 antibody CD115 antibody CD115 antigen antibody CFMS antibody Colony stimulating factor 1 receptor antibody Colony stimulating factor I receptor antibody CSF 1 R antibody CSF 1R antibody CSF-1 receptor antibody CSF-1-R antibody CSF1 R antibody CSF1R antibody CSF1R_HUMAN antibody CSFR antibody EC 2.7.10.1 antibody FIM 2 antibody FIM2 antibody FMS antibody FMS proto oncogene antibody FMS protooncogene antibody HDLS antibody M-CSF Receptor antibody M-CSF-R antibody Macrophage colony stimulating factor 1 receptor antibody Macrophage colony stimulating factor I receptor antibody Macrophage colony-stimulating factor 1 receptor antibody McDonough feline sarcoma viral (v fms) oncogene homolog antibody MCSFR antibody Oncogen FMS antibody Proto-oncogene c-Fms antibody V-FMS McDonough feline sarcoma viral oncogen homolog, formerly antibody
• Abbreviation: Macrophage colony-stimulating factor 1 receptor CSF-1 receptor CSF-1-R CSF-1R M-CSF-R Proto-oncogene c-Fms CD115 CSF1R FMS
• CAS Number: 9000-83-3
• Swiss Prot: P07333 Human
• Cellular Locus: Cell membrane
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within human CSF1R aa 539-972 (Cytoplasmic)
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IHC-P, FC
• Positive Control: Human tonsil tissue, human colon carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: IHC-P: 1:2,000-1:10,000 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 108 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes