TROP2 Mouse Monoclonal Antibody [A5E2]

TROP2 Mouse Monoclonal Antibody [A5E2]

• Description: TROP-2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), pancreatic carcinoma marker protein GA733-1, membrane component chromosome 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thryoglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. TROP-2 plays a role in tranducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Mutations in the gene encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment.
• Product Name Alternative: Cell surface glycoprotein Trop 2 antibody Cell surface glycoprotein Trop-2 antibody Cell surface glycoprotein Trop2 antibody Epithelial glycoprotein 1 antibody GA733 1 antibody GA7331 antibody M1S 1 antibody M1S1 antibody Membrane component chromosome 1 surface marker 1 antibody Pancreatic carcinoma marker protein GA733 1 antibody Pancreatic carcinoma marker protein GA733-1 antibody Pancreatic carcinoma marker protein GA7331 antibody TACD 2 antibody TACD2_HUMAN antibody TACSTD 2 antibody Tacstd2 antibody Trop 2 antibody Trop2 antibody Tumor associated calcium signal transducer 2 precursor antibody Tumor-associated calcium signal transducer 2 antibody
• Abbreviation: TACSTD2
• CAS Number: 9007-83-4
• Swiss Prot: P09758 Human
• Cellular Locus: Membrane.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant protein within human TROP2 aa 1-274 / 323 (Extracellular).
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: MCF7 cell lysate, A431 cell lysate, A431, human skin tissue, human breast cancer tissue, human esophagus tissue, MDA-MB-468.
• Concentration: 2 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:400-1:1,000 ;FC: 1:1,000
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 36 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No