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TROP2 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-60Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-60Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TROP-2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), pancreatic carcinoma marker protein GA733-1, membrane component chromosome 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thryoglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. TROP-2 plays a role in tranducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Mutations in the gene encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment.
CAS Number
9007-83-4
Product Name Alternative
Cell surface glycoprotein Trop 2 antibody Cell surface glycoprotein Trop-2 antibody Cell surface glycoprotein Trop2 antibody Epithelial glycoprotein 1 antibody GA733 1 antibody GA7331 antibody M1S 1 antibody M1S1 antibody Membrane component chromosome 1 surface marker 1 antibody Pancreatic carcinoma marker protein GA733 1 antibody Pancreatic carcinoma marker protein GA733-1 antibody Pancreatic carcinoma marker protein GA7331 antibody TACD 2 antibody TACD2_HUMAN antibody TACSTD 2 antibody Tacstd2 antibody Trop 2 antibody Trop2 antibody Tumor associated calcium signal transducer 2 precursor antibody Tumor-associated calcium signal transducer 2 antibody
Abbreviation
TACSTD2, GA733-1, M1S1, TROP2
Swiss Prot
P09758 Human
Cellular Locus
Membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within RFc-hTROP2 aa 27-274 (Extracellular)/323.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC, IF-Tissue
Positive Control
A431 cell lysates, A431, human lung carcinoma tissue, human liver carcinoma tissue, human colon carcinoma tissue, human breast carcinoma tissue, human esophagus tissue, Hela, human breast carcinoma tissue, human skin tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IF-Tissue: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 36 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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