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FZD2 Rabbit Polyclonal Antibody

CAT: 0992-HA500406Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500406Size:100 µL
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Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. TcdB occupies the binding site for Wnt-adducted palmitoleate in frizzled receptors and TcdB-binding prevents Wnt-binding and downstream Wnt signaling. Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
CAS Number
9007-83-4
Product Name Alternative
Frizzled homolog 2 antibody Frizzled-2 antibody Frizzled2 antibody Fz 2 antibody Fz-2 antibody Fz2 antibody FZD 2 antibody FZD2 antibody FZD2_HUMAN antibody FzE 2 antibody FzE2 antibody hFz 2 antibody hFz2 antibody Mfz10 antibody
Abbreviation
Frizzled-2 Fz-2 hFz2 FzE2 FZD2
Swiss Prot
Q14332 Human, Q9JIP6 Mouse
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within human FZD2 aa 301-327 (Extracellular domain).
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
293 cell lysate, HepG2 cell lysate, Hela cell lysate, mouse heart tissue.
Concentration
2.22 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:600
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 63.5 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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