PSMB7 Rabbit Polyclonal Antibody

CAT: 0992-HA500345Size: 100 µLDry Ice: NoHazardous: No
CAT#:0992-HA500345Size:100 µL
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Description
Proteasome subunit beta type-7 as known as 20S proteasome subunit beta-2 is a protein that in humans is encoded by the PSMB7 gene. The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies. An improved and comprehensive understanding of the pathophysiology of the proteasome should lead to clinical applications in the future. The proteasomes form a pivotal component for the ubiquitin–proteasome system (UPS) and corresponding cellular Protein Quality Control (PQC). Protein ubiquitination and subsequent proteolysis and degradation by the proteasome are important mechanisms in the regulation of the cell cycle, cell growth and differentiation, gene transcription, signal transduction and apoptosis. Subsequently, a compromised proteasome complex assembly and function lead to reduced proteolytic activities and the accumulation of damaged or misfolded protein species. Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to malignancies.
CAS Number
9007-83-4
Product Name Alternative
Macropain chain Z antibody Multicatalytic endopeptidase complex chain Z antibody Proteasome (prosome macropain) subunit beta type 7 antibody Proteasome beta 7 subunit antibody Proteasome catalytic subunit 2 antibody Proteasome subunit alpha antibody Proteasome subunit beta 7 antibody Proteasome subunit beta type-7 antibody Proteasome subunit Z antibody PSB7_HUMAN antibody PSMB7 antibody PUP1 antibody Z antibody
Abbreviation
PSMB7
Swiss Prot
Q99436 Human
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human PSMB7 aa 1-277 / 277.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
SW480 cell lysate, HepG2 cell lysate, Hela cell lysate, human lung carcinoma tissue, human colon tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500;IHC-P: 1:600
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 30 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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