Activin Receptor Type IA Rabbit Polyclonal Antibody

Activin Receptor Type IA Rabbit Polyclonal Antibody

• Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
• Product Name Alternative: Activin A receptor type I antibody Activin A receptor type II like kinase 2 antibody Activin receptor type I antibody Activin receptor type-1 antibody Activin receptor-like kinase 2 antibody ACTR-I antibody ACTRI antibody Acvr1 antibody ACVR1_HUMAN antibody ACVR1A antibody ACVRLK2 antibody ALK 2 antibody ALK-2 antibody ALK2 antibody FOP antibody Hydroxyalkyl protein kinase antibody Serine/threonine-protein kinase receptor R1 antibody SKR1 antibody TGF-B superfamily receptor type I antibody TGFB superfamily receptor type I antibody TSR-I antibody TSRI antibody
• Abbreviation: ACVR1
• CAS Number: 9007-83-4
• Swiss Prot: Q04771 Human, P37172 Mouse, P80201 Rat
• Cellular Locus: Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human Activin Receptor Type IA aa 440-480.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell
• Positive Control: Mouse skeletal muscle tissue lysate, PC-3 cell lysate, rat skeletal muscle tissue lysate, MG-63.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 57 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No