CD45 Recombinant Rabbit Monoclonal Antibody [JE03-05]

CD45 Recombinant Rabbit Monoclonal Antibody [JE03-05]

• Description: Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA). The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to the receptor type PTP family. CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.
• Product Name Alternative: B220 antibody CD 45 antibody CD45 antibody CD45 antigen antibody CD45R antibody GP180 antibody L-CA antibody LCA antibody Leukocyte common antigen antibody loc antibody Ly-5 antibody LY5 antibody Ly5, homolog of antibody Lyt-4 antibody OTTHUMP00000033813 antibody OTTHUMP00000033816 antibody OTTHUMP00000033817 antibody OTTHUMP00000038574 antibody Protein tyrosine phosphatase receptor type c polypeptide antibody Protein tyrosine phosphatase, receptor type C antibody protein tyrosine phosphatase, receptor type, C antibody Protein tyrosine phosphatase, receptor type, c polypeptide antibody Ptprc antibody PTPRC_HUMAN antibody Receptor-type tyrosine-protein phosphatase C antibody T200 antibody T200 glycoprotein antibody T200 leukocyte common antigen antibody
• Abbreviation: Receptor-type tyrosine-protein phosphatase ,Leukocyte common antigen,L-CA,T200,CD45,PTPRC
• CAS Number: 9000-83-3
• Swiss Prot: P08575 Human
• Cellular Locus: Cell junction, Cell membrane, Membrane
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human CD45 aa 1,210-1,306 / 1,306.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC, IF-Tissue, mIHC
• Positive Control: Jurkat cell lysates, human colon cancer tissue, human tonsil tissue, human spleen tissue, Jurkat.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1000 ;IHC-P: 1:1,000 ;FC: 1:50-1:100 ;IF-Tissue: 1:500 ;mIHC: 1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 147 kDa.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes