Phospho-HER3/ErbB3 (Y1222) Recombinant Rabbit Monoclonal Antibody [JE51-89]

• Description:

  The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.

• Product Name Alternative:

  c erbB 3 antibody c erbB3 antibody Erb b2 receptor tyrosine kinase 3 antibody ErbB 3 antibody ERBB3 antibody ERBB3 protein antibody erbB3 S antibody ERBB3_HUMAN antibody Glial growth factor receptor antibody HER 3 antibody HER3 antibody Human epidermal growth factor receptor 3 antibody LCCS2 antibody MDA BF 1 antibody MGC88033 antibody p180 ErbB3 antibody p45 sErbB3 antibody p85 sErbB3 antibody proto-oncogene-like protein c ErbB 3 antibody proto-oncogene-like protein c ErbB3 antibody Proto-oncogene-like protein c-ErbB-3 antibody Receptor tyrosine protein kinase erbB 3 antibody Receptor tyrosine protein kinase erbB3 antibody Receptor tyrosine-protein kinase erbB-3 antibody Tyrosine kinase type cell surface receptor HER3 antibody Tyrosine kinase-type cell surface receptor HER3 antibody v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody

• Abbreviation:

  ERBB3

• Swiss Prot:

  P21860 Human

• Cellular Locus:

  Cell membrane, secreted.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Synthetic phosphopeptide corresponding to a region surrounding Tyrosine 1222 of Human ErbB3.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  MCF7 serum starved for 6 hours then add 10nM Neuregulin-1 for 10 minutes cell lysate, human thyroid tissue, human skin tissue, human placenta tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 148 kDa.

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3